Endocrine Abstracts

Introduction: Diabetes mellitus (DM) is a chronic disease that requires continuous medical care. Health care providers should adopt approaches that improve patient outcomes and adherence.Aims: To evaluate the adherence to Endocrinology ambulatory follow-up after elective hospital admission for decompensated DM and to determine the relationship between adherence and therapeutic success after discharge.Methods: Retrospective study of...

Therapeutic options for patients with severe obesity are limited. Low energy meal replacement regimes can induce significant short-term weight loss and improvements in metabolic variables. We sought to estimate the effect size on adiposity and cardiovascular risk factors of a relatively inexpensive 24-week regime based on meal replacement with semi-skimmed milk in severely obese adults. A retrospective cohort analysis showed that of 206 patients in our hospital-based bariatric...

Introduction: Thyroglobulin (Tg) measurement in needle washouts from fine-needle aspiration biopsies (FNA-Tg) increases the sensitivity of lymph node (LN) metastasis diagnosis in differentiated thyroid cancer (DTC). However, the cutoff value for FNA-Tg has not been clearly established and there are large differences between clinical studies, which hinders its interpretation. Our study aimed to investigate the optimal cutoff value of FNA-Tg and evaluate its utility in the diagn...

Introduction: Familial partial lipodystrophy (FPL) is an autosomal dominant disease characterized by selective loss of subcutaneous fat from the extremities and gluteal region, with lipohypertrophy of the face, neck and trunk. It is usually tightly linked with severe metabolic complications. FPL type 3 results from peroxisome proliferator-activated receptor gamma (PPARG) mutations.Case presentations: Fifty three-year-old woman, referred to endocrinology ...

Introduction: The microvascular complications of diabetes and consequent autonomic neuropathy may cause changes in saliva’s secretion and composition. Hyperglycemic levels can also contribute to various oral pathological changes due to alteration of fungi or bacterial flora and dental biofilm surface, leading to the onset of candidiasis, periodontitis and dental caries. The aim of this study was to determine total bacterial load of saliva and dental biofilm of diabetic pa...

Introduction: Diabetic gastroparesis (DGP) is defined by delayed gastric emptying in the absence of mechanical obstruction caused by autonomic neuropathy. Only 5% of type 1 and 1% of type 2 diabetic patients combine the delay of gastric emptying with typical gastroparesis symptoms. This entity is usually identified in patients with least 10 years of diabetes evolution and is presented typically in the 4th to 5th decades of life in type 1 diabetes mellitus (T1DM). It is associa...

Introduction: Type 1 diabetes (T1D) is an important endocrine disease in the pediatric age group. The shift from pediatrics to adult health care providers is a critical period for adolescents with diabetes.Objective: Characterization of a pediatric population with T1D moved to adult health care between January/2001–April/2015.Methods: Cross-sectional study with retrospective analysis of medical records.R...

Introduction: Pituitary macroincidentalomas are rare, being found in only 0.2%–0.3% of the patients that undergo imaging studies for an unrelated reason. The majority of them are non-functioning adenomas.Case Report: Woman, 77 years-old, with type 2 diabetes mellitus, hypertension and primary hypothyroidism. She was referred to Endocrinology due to a pituitary incidentaloma (18 mm of maximal diameter, with extension to the cavernous sinus and to the...

Background: Mammalian target of rapamycin (mTOR) is a downstream effector of the PI3K/AKT pathway. It can be activated by diverse stimuli, such as growth factors, nutrients, energy, stress signals and signaling pathways such as PI3K, MAPK and AMPK, in order to control cell growth, proliferation and survival. The active form of mTOR (pmTOR) may form two distinct complexes: mTORC1 that activates S6K1 and 4EBP1 which are involved in mRNA translation; and mTORC2 that activates PKC...

Osteopontin (OPN) is a matricellular protein highly expressed in cancer cells, which is able to modulate tumorigenesis and metastasis in several malignancies, including follicular cell-derived thyroid cancers (TC). OPN is one of the gene products aberrantly expressed in TC, but the contribution of each OPN isoform (OPNi), named as OPNa, OPNb and OPNc, is currently unknown. This study aims to analyze the expression profile of OPNi in TC tissue samples, correlate its expression ...